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Page 1 of 2 Anabolic steroids were developed in the late 1930s primarily to treat hypogonadism, a condition in which the testes do not produce sufficient testosterone for normal growth, development, and sexual functioning. The primary medical uses of these compounds are to treat delayed puberty, some types of impotence, and wasting of the body caused by HIV infection or other diseases. During the 1930s, scientists discovered that anabolic steroids could facilitate the growth of skeletal muscle in laboratory animals. This led to abuse of these compounds by bodybuilders and weightlifters and then by athletes in other sports. Anabolic steroids can be taken orally, injected intramuscularly, or rubbed on the skin when in the form of gels or creams. These drugs are often used in patterns called cycling, which involves taking multiple doses of steroids over a specific period of time, stopping for a period, and starting again. Users also frequently combine several different types of steroids in a process known as stacking. By doing this, users believe that the different steroids will interact to produce an effect on muscle size that is greater than the effects of using each drug individually. Another mode of steroid use is "pyramiding." This is a process in which users slowly escalate steroid use (increasing the number of drugs used at one time and/or the dose and frequency of one or more steroids) reaching a peak amount at mid-cycle and gradually tapering the dose toward the end of the cycle. Health Effects Anabolic steroid abuse has been associated with a wide range of adverse side effects ranging from some that are physically unattractive, such as acne and breast development in men, to others that are life threatening. Most of the effects are reversible if the abuser stops taking the drug, but some can be permanent. In addition to the physical effects, anabolic steroids can also cause increased irritability and aggression. Some of the health consequences that can occur in both males and females include liver cancer, heart attacks, and elevated cholesterol levels. In addition to this, steroid use among adolescents may prematurely stop the lengthening of bones resulting in stunted growth. People who inject steroids also run the risk of contracting or transmitting hepatitis or HIV.Some steroid abusers experience withdrawal symptoms when they stop taking the drug. These withdrawal symptoms include mood swings, fatigue, restlessness, loss of appetite, insomnia, reduced sex drive, and depression. This depression can lead to suicide attempts, and if left untreated, can persist for a year or more after the abuser stops taking the drugs.
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